Our optogenetic tools enable precise and dynamic control over any cellular function.

Our tools are cell line agnostic and designed to seamlessly integrate into your process.

Gene Expression Control

Cell state control

Metabolic optimization

Tunable targeted gene expression

Receptor Control

Growth factor replacement

High growth & productivity with light-inducible expression

Conventional constitutive expression fundamentally limits protein production yield and quality, especially for complex or toxic proteins. We provide cell lines that switch from a high-growth phase to a high-expression phase using light. By adjusting illumination, we optimize production for the highest target protein yield.

Direct, precise control of your protein production process

We engineer optogenetic tools into cell lines, enabling precise, light-controlled gene expression that outperforms industry-standard CMV promoters. By dynamically adjusting light intensity and patterns, Prolific enables regulation of any target gene’s expression—at any time and to any desired level, delivering superior performance and control beyond conventional systems. Here, CHO cells were stably engineered for reporter protein production under control of the constitutive CMV promoter or different light-inducible promoters in the same genomic safe harbor locus. PLight-1-6 are different light-inducible promoters that differ in their maximal expression strength and dynamic range.

Our technology solves your toughest protein challenges.

Gene expression control

By attaching light-sensitive proteins to transcription factors to enable light-induced gene expression, we can deliver decoupled growth and production, tunable gene expression, and metabolic optimization. This enables increased target protein productivity, quality, and consistency along with higher viable cell densities.

Receptor control

By attaching light-sensitive proteins to dimerizing growth factor receptor components, we use light to control growth factor signaling pathways. Temporal light control over receptor activation replaces the need for costly growth factors or proteins, thereby reducing the cost of production, shortening production runs, and simplifying media requirements.

Having yield issues? Contact us for a risk-free manufacturability assessment.

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